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Fig. 8 | Journal of Experimental & Clinical Cancer Research

Fig. 8

From: Notch1 signaling pathway promotes invasion, self-renewal and growth of glioma initiating cells via modulating chemokine system CXCL12/CXCR4

Fig. 8

Model of the mechanism of Notch1 signaling and CXCL12/CXCR4 axis in GICs self-renewal, invasion and tumor growth. CXCR4 positive glioma cells, usually expressed Notch1 both and dispersed in the periphery of the tumorsphere. Notch1 signaling promotes the self-renewal, invasion and tumor growth of glioma initiating cells via AKT/mTOR pathway activity medicated by CXCL12/CXCR4 axis

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Journal of Experimental & Clinical Cancer Research

ISSN: 1756-9966

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