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Fig. 3 | Journal of Experimental & Clinical Cancer Research

Fig. 3

From: Curcumin: a therapeutic strategy in cancers by inhibiting the canonical WNT/β-catenin pathway

Fig. 3

Circadian clock genes. The clock consists of a stimulatory loop, with the Bmal1/Clock heterodimer stimulating the transcription of Per and Cry genes, and an inhibitory feedback loop with the Per/Cry heterodimer translocating to the nucleus and repressing the transcription of the Clock and Bmal1 genes. An additional loop involves the RORs and RevErbs factors with a positive feedback by ROR and a negative feedback by RevErbs

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