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Fig. 7 | Journal of Experimental & Clinical Cancer Research

Fig. 7

From: Hsa_circ_0058124 promotes papillary thyroid cancer tumorigenesis and invasiveness through the NOTCH3/GATAD2A axis

Fig. 7

Hsa_circ_0058124 promotes PTC progression through NOTCH3 signaling pathway. a Heatmap representation of the significantly differentially expressed genes from RNA-seq data after treatment with the indicated siRNAs. b KEGG enrichment focused on a set of signaling pathways after hsa_circ_0058124 silencing, summarized based on the enrichment score. c, d GSEA analysis of the “KEGG_NOTCH_SIGNALING_PATHWAY” gene set in the si-NC versus si-hsa_circ_0058124 group in TPC-1 cells. The top portion of the figure plots the enrichment scores for each gene, whereas the bottom portion of the plot shows the value of the ranking metric moving down the list of ranked genes. Y-axis: value of the ranking metric; X-axis: the rank for all genes. NES, normalized enrichment score. e The mRNA levels of the related genes in the NOTCH signaling pathways in TPC-1 cells treated with si-hsa_circ_0058124. f NOTCH3 and HES1 protein levels in TPC-1 and K1 cells with hsa_circ_0058124 deficiency. Values are expressed as the mean ± S.E.M, n = 3 in a, b, c, d. *P < 0.05, **P < 0.01 and ***P < 0.001

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