Fig. 4

Anaylsis of cell cycle progression and Caspase3/7 activity in T24 cells with mono- or combination therapies (a) Analysis of cell-cycle progression of T24 cells 72 h after mono- or combination therapies as depicted (Data represent the mean ± SD of 3 replicates). b Caspase3/7 activity was measured and normalized to CTB results after 72 h of treatment (*, P < 0.05; one-way ANOVA with Dunnett’s multiple comparisons test, and unpaired t-test; NS not significant, Data represent mean ± SD of 3 replicates). Concentrations used were Palbociclib (1000 nM), Axitinib (1000 nM), Erdafitinib (5000 nM), NVP-BEZ235 (200 nM) and CI1040 (1000 nM)