Table 2 Inhibitors/agonists for combination therapy with Palbociclib
Inhibitors/agonists | Target | Pathway |
|---|---|---|
PIK-90 | PI3Kα/γ/δ | PI3K-AKT |
MK2206 | Akt1/2/3 | PI3K-AKT |
Everolimus | mTOR | PI3K-AKT |
NVP-BEZ235 | p110α/γ/δ/β and mTOR | PI3K-AKT |
Axitinib | VEGFR1/2/3, PDGFRβ and c-Kit | Ras/MAPK |
Erdafitinib | FGFR1/2/3/4 | Ras/MAPK |
CI-1040 | MEK1/2 | Ras/MAPK |
Ruxolitinib | JAK1/2 | JAK-STAT |
Stattic | STAT3 | JAK-STAT |
SH-4-54 | STAT3/5 | JAK-STAT |
Roscovitine | CDK2/7/9 | Cell cycle |