Fig. 3

ImmunoPET imaging and ex vivo biodistribution analysis with ¹²⁴I-scFvD2B of experiment #4. a One representative Immuno-PET images after intravenous administration of 7.4 MBq ¹²⁴I⁻scFvD2B (433 MBq/mg). PC3 (PSMA negative, right flank) and PC3-PIP (PSMA positive, left flank) tumours evaluated 15 and 24 h post injection. Bladder is also indicated by an arrow. The imaging is so clean in the irrelevant organ that it is barely visible the shape of the mice. b Ex vivo biodistribution analysis in PC3 and PC3-PIP tumour bearing mice evaluated 15 h (2 mice) and 24 h (3 mice) post injection of ¹²⁴I-scFvD2B. Uptake and retention were measured in different organs and illustrated both as decay-adjusted percentage of the injected dose per gram of tissue (% ID/g) and T/B