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Fig. 1 | Journal of Experimental & Clinical Cancer Research

Fig. 1

From: Soluble fibrinogen-like protein 2 promotes the growth of hepatocellular carcinoma via attenuating dendritic cell-mediated cytotoxic T cell activity

Fig. 1

FGL2-antibody treatment or Fgl2 knockout inhibits the growth of subcutaneously (s.c.) transplanted murine hepatoma. a BNL cells (8 × 106) were inoculated s.c. into BALB/c mice, and c C57BL/6 mice were injected s.c. with 8 × 106 Hepa1–6 cells. In the anit-FGL2 group, mice were injected with 100 μg anti-FGL2 (ɑ-FGL2) or isotype dissolved in 100 μL phosphate-buffered saline every 3 days after the tumor size exceeded 100 mm3. Tumor volumes were measured every 2 days. b BNL cells (8 × 106) were inoculated s.c. into Fgl2−/− or WT BALB/c mice, and d Fgl2−/− and WT C57BL/6 mice were injected s.c. with 8 × 106 Hepa1–6 cells. Tumor volumes were measured every 2 days. *P < 0.05, **P < 0.01, ***P < 0.001 (two-tailed unpaired Student’s t test) as compared with the control

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