Fig. 1

Cycling of Ras homolog gene family member C (RhoC) between active and inactive forms: The switching of RhoC between the inactive GDP-bound form to the active GTP-bound form is regulated by Guanine Nucleotide Exchange Factors (GEFs), GTPase Activating Proteins (GAPs) and Guanine Dissociation Inhibitors (GDIs). Binding to GTP changes the conformation of the molecule, thus allowing the binding of various downstream effectors of RhoC like Diaphanous Related Formin (mDia) and Rho Associated Coiled-Coil Containing Protein Kinase (ROCK), thereby facilitating various downstream signaling pathways