Fig. 3

GAS5 over-expression enhanced sensitivity to DDP in OC cells both in vitro and in vivo. a DDP sensitivity were detected by CCK8 assay and IC50 in OC cell lines SKOV3 and HEY. b The tumor tissues of nude mice were presented. c The volume of tumor was calculated on the 7, 9, 12, 14, 17, 19, 21, 23, 25 and 28 days. And the tumor weight were measured when tumors were harvested. d Immunohistochemical staining were performed to detect the Ki67, CDK4 and PARP1 expression in animal tumor tissues. *P < 0.05 versus control groups