Fig. 5

The relationship between RUNX1 and KIT. a Enrichment analysis of GO-Biological Precell with RUNX1 Expression was shown. b Interactive information of the first three biological process in Fig. 5a was shown using Venn Diagram (http://bioinfogp.cnb.csic.es/tools/venny/index.html). c Mutual effects between KIT and other proteins was shown using a protein association networks data set of STRING. d Expression of KIT protein detected by western blot in HCT116/vector, HCT116/RUNX1, SW480/scramble and SW480/shRUNX1 groups. e Expression of KIT protein and targeted genes activated by Wnt signaling pathway in HCT116 cells with RUNX1-overexpressed or KIT-silencing. f The genomic regions of KIT gene are located in two regions, one is a promoter region (+700pb) and the other is an enhancer region (+ 30 kb). Co-immunoprecipitation assay observed RUNX1 interacts with KIT both in the enhancer region and promoter region