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Fig. 6 | Journal of Experimental & Clinical Cancer Research

Fig. 6

From: RUNX1 promotes tumour metastasis by activating the Wnt/β-catenin signalling pathway and EMT in colorectal cancer

Fig. 6

RUNX1 promotes colorectal cancer progression via RUNX1-Wnt/β-catenin signaling feedback loop. a Migration and invasion ability measured by Transwell assays in HCT116/RUNX1、RKO/RUNX1 、HCT116/Vector and RKO/Vector cells with the XAV939 (0/10 μM) treated. b Expression of EMT-related molecules by western blot in HCT116/vector and HCT116/RUNX1 cells with the XAV939 (10 μM) treated. c Expression of RUNX1 detected by western blot analysis and qPCR in HCT116 and SW480 cells with β-catenin silencing. d Hypothesized signal mechanism of RUNX1 in the development of CRC

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