Fig. 6

Toxicity assessment of GrB-Fc-4D5 in BALB/c mice. a Body weight in control group (PBS) and Grb-Fc-4D5-treated (100 mg/kg) mice. The values represent the weights measured in BALB/c mice before treatment, one day after treatment (acute group) and 4 weeks after treatment (recovery group). b Liver enzymes detected in serum of BALB/c treated mice. The enzymatic activity of Alanine Transferase (SGPT), Aspartate transferase (SGOT) and Lactate Dehydrogenase (LDH) was measured in acute and recovery groups. No statistical difference was found between mice treated with control or GrB-Fc-4D5 in the acute or recovery groups