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Table 2 Cytotoxic effects of GrB-Fc-4D5 and GrB(S195A)-Fc-4D5 on various tumor cell lines

From: Development of a human immuno-oncology therapeutic agent targeting HER2: targeted delivery of granzyme B

Cell Line

IC50 (nM)

GrB-Fc-4D5

GrB(S195A)-Fc-4D5

SKBR3

43

1494

MDA-MB-453

22

2294

A-549

49

887

MDA-MB-231

40

685

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Journal of Experimental & Clinical Cancer Research

ISSN: 1756-9966

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