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Table 3 Cytotoxic effects of GrB-Fc-4D5 and Kadcyla on log phase and confluent tumor cell lines

From: Development of a human immuno-oncology therapeutic agent targeting HER2: targeted delivery of granzyme B

Cell Line

GrB-Fc-4D5 IC50 (nM)

Kadcyla IC50 (nM)

Log phase

Confluent

Log phase

Confluent

SKBR3

56

64

< 0.04

< 0.04

HT-29

36

127

41

121

MDA-MB-231

27

58

44

79

A-549

55

68

78

76

DU-145

13

25

125

205