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Table 5 Macroscopic and microscopic findings in the different organs and tissues extracted from mice in acute and recovery groups

From: Development of a human immuno-oncology therapeutic agent targeting HER2: targeted delivery of granzyme B

Organ Morphologic Diagnosis

Acute

Recovery

PBS

GrB-Fc-4D5

PBS

GrB-Fc-4D5

Liver/Gall Bladder

N

A

A

A

Inflammation, chronic, multifocal, interstitium

 

0.2

0.2

0.2

Kidneys

A

N

A

N

Inflammation, chronic, focal, interstitium, pelvis

0.2

 

0.2

 

Karyomegaly & atypia, focal, interstitium

    

Lung

A

N

N

A

Histiocytosis, focal, alveoli

0.2

  

0.2

Inflammation, chronic, multifocal, perivascular

   

0.8

Ectopic tissue, focal, bone, bronchiole

   

0.2

Embolism, foreign body with inflammation, chronic-active, focal, interstitium

    

Adenoma/adenocarcinoma, alveolar-bronchiolar

    

Spleen

N

A

A

A

Hyperplasia, lymphoid, diffuse, white pulp

 

1.2

0.4

0.4

Heart

N

A

N

A

Inflammation, chronic, focal, interstitium, myocardium

 

0.6

 

0

Skeletal muscle

N

N

N

N

Aorta (thoracic)

N

N

N

N

Adrenal Glands

N

A

A

A

Degeneration, X-zone, multifocal, corticomedullary junction

 

1

1.6

1.8

Hyperplasia, spindle cells, multifocal, subcapsular

  

1.2

0.8

Brain

N

N

N

N

Cyst, epidermal inclusion

    

Gliosis, multifocal, neuropil with apoptotic cells

    

Nose

A

A

A

A

Infiltration, lymphocytes, multifocal, submucosal, nasal mucosa & lacrimal duct

0.8

0.8

0.8

0.2

Degeneration, multifocal, skeletal muscle

0.4

   

Regeneration, multifocal, skeletal muscle

0.4

   

Malformation, focal, septum & turbinates

 

0.4

 

malformation

Eyes, Ears

N

N

N

A

Inflammation, acute, multifocal, dermal, bilateral, external ear with mild, acanthosis & hyperkeratosis

   

0.2

Inflammation, acute, diffuse, bilateral, middle-ear

    

Pituitary Gland

N

N

N

0

Sciatic Nerve

N

N

N

N

Spinal cord

A

N

N

A

Degeneration, myofibers, multifocal, paravertebral muscles with mineralization

0.6

   

Inflammation, chronic-active, focal, paravertebral skeletal muscle

   

0.6

Stomach

A

A

A

A

Inflammation, acute, multifocal, submucosal

1.2

1.4

1.2

1.8

Hyperkeratosis, diffuse, forestomach with bacterial colonies

1

0.8

  

Depletion, Parietal cells, multifocal, mucosa

 

1.2

1.2

1.6

Metaplasia, intestinal, multifocal, mucosa

 

0.4

  

Hyperplasia, epithelial, multifocal, mucosa

    

Duodenum

A

A

A

A

Hyperplasia, epithelial, diffuse, mucosa

2

2

1.6

1.4

Inflammation, acute, multifocal, submucosal

0.6

1.8

0.8

1

Pancreas

N

N

A

A

Degeneration, acinar cells, focal, parenchyma with chronic inflammation and hemosiderosis

  

0.4

 

Inflammation, chronic, multifocal, interstitium

   

0.4

Jejunum

A

A

A

A

Hyperplasia, epithelial, diffuse, mucosa

1.6

1.8

1

1.6

Inflammation, acute, multifocal, submucosal

 

1

0.6

1

Ileum

A

A

A

A

Hyperplasia, epithelial, diffuse, mucosa

1.2

1.4

1.4

1.4

Inflammation, acute, multifocal, submucosal

0.6

1.2

0.6

1

Cecum

A

A

A

A

Hyperplasia, epithelial, multifocal, mucosa

1.2

1.6

1

1

Inflammation, acute, multifocal, submucosal

0.4

1.2

1

0.8

Colon and Rectum

A

A

A

A

Hyperplasia, epithelial, multifocal, mucosa

0.8

1

1.2

0.6

Inflammation, acute, multifocal, submucosal

 

0.6

1

0.4

Mesenteric Lymph Node

N

A

A

A

Hyperplasia, lymphoid, multifocal, cortex

 

0.8

0.2

0.6

Salivary Gland

N

N

A

N

Inflammation, chronic, multifocal, interstitium

  

0.2

 

Regeneration, acinar cells, focal, periductular

    

Mandibular Lymph Node

N

N

N

A

Hyperplasia, lymphoid, diffuse, cortex

   

0.8

Thymus

N

N

N

N

Thyroid Gland

A

0

A

N

Ectopic tissue (thymus)

ectopic tissue

 

ectopic tissue

 

Parathyroid

A

0

 

N

Cyst, ultimobranchial

cyst

   

Hyperplasia, diffuse, epithelial

    

Trachea

N

N

N

N

Esophagus

N

N

N

A

Hyperkeratosis, diffuse, lumen with bacterial colonies

    

Inflammation, focal, submucosal

    

Skin

A

A

 

0.8

Dermatitis, chronic-active, multifocal, dermis and epidermis

0.2

0.6

  

Mammary Gland

N

A

N

N

Inflammation, chronic, focal, periductular

    

Hyperplasia, epithelial, focal, subcutaneous

 

0.2

  

Urinary Bladder

N

A

N

A

Inflammation, acute, multifocal, submucosal

 

0.2

  

Inflammation, chronic-active, multifocal, submucosal

   

0.4

Ovary

N

N

N

N

Uterus

A

A

A

N

Hydrometra, diffuse, lumen

0.6

0.4

0.4

 

Femur/Knee Joint

N

N

N

A

Inflammation, acute, multifocal, periosteal

   

0.4

Degeneration, focal, myocytes, skeletal muscle, periosteal

    

Regeneration, focal, myocytes, skeletal muscle, periosteal

    

Proliferation, focal, synovial membrane

    

Sternum

N

N

N

A

Inflammation, acute, multifocal, periosteal

   

0.4

  1. N No significant lesion
  2. A = Lesion observed
  3. Grade 1 = minimal, rare < 10%
  4. Grade 2 = mild, infrequent 10–20%
  5. Grade 3 = moderate, frequent 20–50%
  6. Grade 4 = marked, extensive > 50%
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Journal of Experimental & Clinical Cancer Research

ISSN: 1756-9966

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