Fig. 1

TET1 is downregulated in pancreatic tumors. a TET1, b TET2, and c TET3 mRNA levels in pancreatic tumor tissues verses adjacent non-tumor tissues. Data are shown as log2-fold changes (tumor/normal). Results were analyzed by Student’s t-test. d 5-hmC and 5-mC levels in pancreatic tumor tissues verses adjacent non-tumor tissues were detected by dot blot. e IHC analysis of TET1 in pancreatic tumor tissues and adjacent non-tumor tissues (Original magnification, 20×. Enlarged graph, 80×). f Kaplan–Meier analysis of overall survival in 63 patients with pancreatic cancer