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Fig. 3 | Journal of Experimental & Clinical Cancer Research

Fig. 3

From: TET1-mediated DNA hydroxymethylation activates inhibitors of the Wnt/β-catenin signaling pathway to suppress EMT in pancreatic tumor cells

Fig. 3

TET1 suppresses pancreatic cell migration, invasion, and EMT. a and b Wound healing assay for TET1-KO, TET1-OE, TET1-MUT, and NC cell migration at 0, 24, and 48 h (left), calculated data (right), **P < 0.01. c and d Transwell assays revealed that overexpression of wild type but not mutant TET1 inhibited cell migration and invasion, while TET1 knockout accelerated migration and invasion, ** P < 0.01. e and f. Western blot analysis of epithelial markers and mesenchymal markers in BXPC-3 and SW1990 cells

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