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Fig. 2 | Journal of Experimental & Clinical Cancer Research

Fig. 2

From: ANLN-induced EZH2 upregulation promotes pancreatic cancer progression by mediating miR-218-5p/LASP1 signaling axis

Fig. 2

ANLN functioned as an oncogene in pancreatic cancer. a, The ANLN protein expression levels in BxPC-3 and SW1990 cells transfected with ANLN siRNA (ANLN RNAi) or the scramble control (NC) were analyzed by Western blot. b, Proliferation of BxPC-3 and SW1990 cells transfected with ANLN siRNA (ANLN RNAi) or the scramble control (NC) was determined by the CCK-8 assay. c, ANLN knockdown significantly inhibited the colony forming ability of BxPC-3 and SW1990 cells. d and e, The migration and invasion properties of the same cells described in b were determined by the transwell migration and invasion assay. f, Knockdown effect of ANLN silencing lentiviral vectors was confirmed by Western blot. g, ANLN knockdown in BxPC-3 cells repressed the tumor growth. n = 5 per group. **P < 0.01

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