Fig. 6

CWP232291 inhibits the growth of prostate cancer xenografts. a Mice bearing 22Rv1 tumors were treated with CWP232291 (28 days, 50 mg/kg/day or 100 mg/kg/day). Changes in tumor volume of the 22Rv1 xenografted mice are shown. Results are expressed as the means ± SD of six mice. b Body weight of the 22Rv1 xenografted mice is shown. Results are expressed as means ± SD. c Tumor weight of the 22Rv1 xenografted mice is shown. Results are expressed as means ± SEM. *P < 0.05 by one-way ANOVA. d Representative tumors of the 22Rv1 xenografted mice. e Western blot analysis of β-catenin, cleaved caspase-3, and GAPDH in 22Rv1 in two pairs of xenografted tumors. One western blot was randomly selected from the control group and one from the treatment group. Western blots were performed in triplicates and repeated independently three times