Fig. 4
From: Metformin targets a YAP1-TEAD4 complex via AMPKα to regulate CCNE1/2 in bladder cancer cells
Yap1 interacts with TEAD4 in the BLCA cells. a. The expressions of TEAD1–4 in tumor and normal tissues were analyzed and compared using RNA-seq data from TCGA. T stands for tumor tissues (n = 404) and N stands for the normal tissues (n = 28). b. The correlation analysis between TEADs and Yap1 was performed using the RNA-seq data from TCGA. c. The analysis of correlation expression between TEAD4 and CCNE1/2 was established using the RNA-seq data from TCGA. d. Wester Blot was used to detect the interaction between Yap1 and TEAD4 after co-immunoprecipitation (Co-IP) was performed. e. Wetstern Blot was used to determine the expressions of CCNE1 and CCNE2 in T24 and Sw780 cells interfered by TEAD4-siRNAs