Fig. 10From: Peglated-H1/pHGFK1 nanoparticles enhance anti-tumor effects of sorafenib by inhibition of drug-induced autophagy and stemness in renal cell carcinomaSchematic illustration of HGFK1 and sorafenib exhibiting synergistic anti-tumor effects on RCC. In brief, sorafenib could induce autophagy via activating NF-κB signaling pathway, and then enhance the cancer stemness of RCC resulting in drug resistance. But HGFK1 could inhibit the activation of NF-κB induced by sorafenibBack to article page