Fig. 2

Effect of sorafenib and HGFK1 on tumor growth in vivo. Tumor-bearing mouse model was subcutaneously established by implantation of Ketr-3 cells in nude Blab/c mouse. a Schematic diagram illustrated the therapeutic schedule according to the materials and methods. b Tumor volume was measured every 3 days, and all data shown represent the mean ± SD from ten independent mice. c The survival curve of tumor-bearing mice was analyzed with the Log-rank (Mantel-Cox) test. d Ki-67 was stained with IHC. e The expression of Ki-67 was analyzed and quantified with IOD (Integrated Option Density), and all data shown represent the mean ± SD from four independent mice. Significant differences are denoted by * for p < 0.05, ** for p < 0.01, and *** for p < 0.001