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Fig. 4 | Journal of Experimental & Clinical Cancer Research

Fig. 4

From: Dropwort-induced metabolic reprogramming restrains YAP/TAZ/TEAD oncogenic axis in mesothelioma

Fig. 4

Dropwort treatment induces a perturbation in the metabolic profile of MSTO-211H cell lines. a-f Metabolic response of MSTO-211H cell lines to Fil.v. extract treatment. PCA models built on the 1H-NMR dataset of media samples (a) and hydrophilic (b) and lipophilic (c) cell extracts from Fil.v. extract-treated and vehicle-treated MSTO-211H cell cultures. The score plots show metabolic differences between the two cell groups (p = 0.001 and p = 0.01 on PC1 for models in A e B respectively and linear discriminant analysis on PC1 and PC3 for model in (c): p = 0.017. The panels d-f show the fold changes relative to vehicle-treated samples (means±S.D.; *p < 0.05) of the most discriminant metabolites between the two groups from the PCA models (loadings ≥0.8). “c” and “p” for each extracellular metabolite indicate consumption or production, respectively

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