Fig. 8

Dropwort extract exerts broad anticancer effects on MPM cells affecting cell proliferation, viability, migration, metabolism and in vivo tumor growth of MPM cell lines. This occurs by impairing simultaneously several pathways commonly deregulated in human cancers. In particular the PI3K/PTEN/AKT/mTOR signaling and the LKB1/AMPK axis indicated with blue arrows and green arrows, respectively. This perturbation leads to the Hippo pathway inhibition through the ubiquitin-mediated degradation of its oncogenic transducers, YAP and TAZ. Green and red arrows indicate activation and inhibition, respectively