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Fig. 5 | Journal of Experimental & Clinical Cancer Research

Fig. 5

From: LncRNA FLVCR1-AS1 mediates miR-513/YAP1 signaling to promote cell progression, migration, invasion and EMT process in ovarian cancer

Fig. 5

The expression levels of YAP1 and the correlation between FLVCR1-AS1 and YAP1 in OSC cells. a, b The mRNA and protein expression levels of YAP1 were significantly elevated in OSC tissues compared with adjacent normal tissues. c, d YAP1 si-RNA was transfected into SKOV3 and OVCAR3 cells, and the transfection efficiency was verified using qRT-PCR and western blot assays. e, f Colony formation and soft agar growth assays revealed that the colonies generated of both cells were decreased when YAP1 expression was inhibition. g, h, i YAP1 protein and mRNA expression levels were greatly reduced by FLVCR1-AS1 knockdown in OSC cell lines. j FLVCR1-AS1 mRNA expression was reduced following YAP1 inhibition in both cell lines. k A positive correlation was observed between FLVCR1-AS1 and YAP1 mRNA expressions in human OSC tissues. The data were presented as mean ± SD of three independent experiments. **P < 0.01

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