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Fig. 5 | Journal of Experimental & Clinical Cancer Research

Fig. 5

From: Inhibition of COX-2, mPGES-1 and CYP4A by isoliquiritigenin blocks the angiogenic Akt signaling in glioma through ceRNA effect of miR-194-5p and lncRNA NEAT1

Fig. 5

Inhibition of COX-2, mPGES-1 and CYP4A by ISL decreases FGF-2, TGF-β and VEGF production via Akt signaling. a FGF-2, G-CSF, PDGF, TGF-β, Tie-2 and VEGF in the C6 and U87 glioma cells were determined by qPCR. b FGF-2, TGF-β and VEGF in the C6 and U87 glioma cells were determined by ELISA. c Akt and p-Akt were determined in C6 and U87 glioma cells by Western blot. d The effects of Akt overexpression on Akt and p-Akt protein level in C6 and U87 glioma cells were measured by Western blot. e-g FGF-2, TGF-β and VEGF in the C6 and U87 glioma cells were determined by ELISA. Each value represents the mean ± SEM of three independent triplicate experiments. *P < 0.05, **P < 0.01 vs. control, #P < 0.05, ##P < 0.01 vs. ISL (20 μM)-treated group

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