Fig. 2From: Cancer therapeutics using survivin BIRC5 as a target: what can we do after over two decades of study?Summary of the experiment-supported FL118-relevant mechanisms of action: FL118 was demonstrated to (1) inhibit multiple cancer-associated survival and treatment-resistant proteins (survivin, Mcl-1, XIAP, cIAP2, MdmX, ERCC1/6); and (2) bypass additional treatment resistant factors (efflux pump proteins ABCG2 and Pgp, mutated Kras, mutated p53 and mutated APC)Back to article page