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Fig. 2 | Journal of Experimental & Clinical Cancer Research

Fig. 2

From: LncRNA AFAP1-AS1 promotes tumorigenesis and epithelial-mesenchymal transition of osteosarcoma through RhoC/ROCK1/p38MAPK/Twist1 signaling pathway

Fig. 2

Effect of AFAP1-AS1 knockdown on the apoptosis, cell cycle, migration, invasion, actin filament integrity and vasculogenic mimicry formation of OS cells. a and b AFAP1-AS1 knockdown induced apoptosis and resulted in G0/G1 cell cycle arrest. c and d AFAP1-AS1 knockdown inhibited migration and invasion ability of OS cells. e In the AFAP1-AS1 knockdown group, the expression of cleaved Caspase 3, Bax were increased and the expression of Bcl-2, Cyclin D1 and MMP-9 were decreased compared to the scrambled group. f AFAP1-AS1 knockdown inhibited the VM formation ability of OS cells. g AFAP1-AS1 knockdown in OS cells induced loss of actin filament integrity. The integrity and fluorescence intensity of actin filament in osteosarcoma cells were obviously decreased. *P < 0.05, **P < 0.01

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