LncRNA LINC00460 promotes EMT in head and neck squamous cell carcinoma by facilitating peroxiredoxin-1 into the nucleus

Table 1 Relationship between LINC00460 level and clinicopathologic features (N = 123)

Characteristics	No. of Patients		LINC00460 ΔCt^a Mean ± SD	Non-parametric test value	p value
Characteristics	No.	%	LINC00460 ΔCt^a Mean ± SD	Non-parametric test value	p value
Age (years)
≥ 60	81	65.85	8.553 ± 2.175	Z = 0.277	0.782
< 60	42	34.15	8.607 ± 2.906	Z = 0.277	0.782
Gender
Male	84	68.29	8.645 ± 2.758	Z = 0.386	0.700
Female	39	31.71	8.412 ± 1.555	Z = 0.386	0.700
Tumor Size (cm)
≤ 4	73	59.35	8.745 ± 2.548	Z = 0.608	0.543
> 4	50	40.65	8.319 ± 2.268	Z = 0.608	0.543
Lymph Node Metastasis
pN1 to pN3	63	51.22	8.022 ± 2.210	Z = 2.436	0.015 ^*
pN0	60	48.78	9.231 ± 2.635	Z = 2.436	0.015 ^*
TNM Stage
I	11	8.94	9.991 ± 3.331	H = 4.052	0.256
II	28	22.76	9.087 ± 2.559
III	19	15.45	8.147 ± 2.719
IV	65	52.85	8.233 ± 2.028
Pathological Differentiation
Well	85	69.11	8.810 ± 2.122	Z = 2.094	0.036 ^*
Moderately/poorly	38	30.89	8.038 ± 2.990	Z = 2.094	0.036 ^*
Tumor Site
Tongue	42	34.15	8.812 ± 1.928	H = 3.411	0.492
Gingival	36	29.27	8.293 ± 2.304
Cheek	25	20.32	8.122 ± 2.246
Floor of Mouth	6	4.88	8.802 ± 1.548
Oropharynx	14	11.38	8.775 ± 3.268
Local Invasion
No	87	70.73	8.550 ± 2.604	Z = 0.183	0.854
Yes	36	29.27	8.624 ± 2.011	Z = 0.183	0.854
Tumor Type
Primary	105	85.37	8.723 ± 2.493	Z = 1.782	0.075
Recurrence	18	14.63	7.684 ± 1.907	Z = 1.782	0.075

Abbreviations: SD standard deviation, pN pathological lymph node status
^aThe ΔCt value was determined by subtracting the GAPDH Ct value from the LINC00460 Ct value. Smaller ΔCt values indicate higher expression. *p<0.05

ISSN: 1756-9966