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Fig. 4 | Journal of Experimental & Clinical Cancer Research

Fig. 4

From: Tumor vasculature remolding by thalidomide increases delivery and efficacy of cisplatin

Fig. 4

Thal enhances blood perfusion and supresses vascular destabilization. a Micrographs of FITC-conjugated lectin (Green) and CD31 (Red) stained vessels in tumor tissues from 4 T1 and CT26 models. FITC-lectin was intravenously injected at 30 min before euthanasia (n = 5). Arrowheads denote perfused vessels. Bars: 50 μm. b Quantification of vessel perfusion in 4 T1 and CT26 tumors. Lectin+ area is presented as a percentage per total sectional area. c Scanning electron microscopy and comparisons of the vascular congestion in 4 T1 and CT26 tumors. Yellow arrows indicate vessels plugged with red blood corpuscles; white arrowheads indicate open vascular lumens with less erythrocyte clot. Bars: 30 μm. d Quantification of percentage of clogged vessels in 4 T1 and CT26 tumors. e Images and comparison of dextran leakage of tumor vessels in 4 T1 and CT26 models. TRITC-dextran was intravenously injected at 30 min before euthanasia (n = 5). Bars: 50 μm. f Quantification of vessel leakage in 4 T1 and CT26 tumors. Dextran+ area is presented as a percentage per total sectional area. Quantitative data are represented as mean ± SD. All p values were calculated by one-way ANOVA analysis followed by Dunnett’s multiple comparison test. *p < 0.05, ** p < 0.01, ***p < 0.001

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