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Fig. 6 | Journal of Experimental & Clinical Cancer Research

Fig. 6

From: Tumor vasculature remolding by thalidomide increases delivery and efficacy of cisplatin

Fig. 6

Thal combined with CPt suppresses metastasis and prolongs overall survival. a Schematic diagram depicting generation of 4 T1 spontaneous metastasis model and schedules for injection and analyses. Four weeks after 4 T1 cells inoculation, tumor-bearing mice were given intraperitoneal injections of vehicle, Thal, CPt or Thal + CPt at indicated time points. b Micrographs of lung sections stained for H&E. Metastatic colonies are viewed under higher magnification (Right panels). Bars: 500 μm (Left), 50 μm (Right). c Quantification of metastatic nodule area presented as a percentage of total lung section area. d Micrographs and comparison of CPt+ area in lungs. CPt-DNA adducts were immunostained (Arrows), and CPt+ area is measured as a percentage per total sectional area. Bars: 50 μm. e Kaplan-Meier survival curves of mice on 4 T1 spontaneous metastasis model (n = 8). Data were analyzed by the log-rank test. *p < 0.05

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