Fig. 1

High expression of S1PR1 was correlated with poor prognosis of ESCC patients. a. Representative images from immunohistochemically staining of S1PR1 and Ki-67 in ESCC patient tissues. b. Pearson correlation analysis of the expression of S1PR1 and Ki-67 in ESCC tissues. Statistical significance was determined by Student’s t test. p < 0.05. c. The Kaplan-Meier survival curve of overall survival (OS) according to S1PR1 immunostaining in 127 cases of ESCC patients. Patients with high S1PR1 expression have shorter OS than those with low S1PR1 expression (log-rank test, P < 0.01). d. Pearson correlation analysis of S1PR1 mRNA expression and cell proliferation ability in ESCC cell lines. Statistical significance was determined by Student’s t test, p < 0.05