Fig. 7

Identification of the miR-504/FZD7 ratio as a ME subtype marker in GBM. a Distribution of the miR-504/FZD7 ratio between ME subtype GBM (n = 172) and PN subtype GBM (n = 105) in TCGA. b Chi-square analysis of the relationship between the miR-504/FZD7 ratio and molecular subtype. c The expression patterns of ME and PN signature genes corresponding to the miR-504/FZD7 ratio. d Pearson correlation analysis of the miR-504/FZD7 ratio and ME score in TCGA. e PCA based on ME signature genes and EMT signature genes showed distinct distribution patterns between GBM of high- and low-ratio groups. f GO analysis of top 200 genes negatively related to the miR-504/FZD7 ratio. g GO analysis of top 200 differentially upregulated genes in low–miR-504/FZD7 ratio tumors in TCGA. h GSEA comparison of ME phenotype between high- and low–miR-504/FZD7 ratio cases. i Clustering of GSVA scores and analyses of biological processes associated with the miR-504/FZD7 ratio in GBM according to TCGA dataset (GO:0007158, neuron cell–cell adhesion; GO:2000047, regulation of cell–cell adhesion mediated by cadherin; GO:0060231, mesenchymal to epithelial transition; GO:0097150, neuronal stem cell population maintenance; GO:2000036, regulation of stem cell population maintenance). ***P < 0.001