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Table 1 Univariate and multivariate Cox regression analysis of overall survival in 517 patients with GBM

From: miR-504 suppresses mesenchymal phenotype of glioblastoma by directly targeting the FZD7-mediated Wnt–β-catenin pathway

Variable

Univariate regression

Multivariate regression

HR (95%CI)

P-value

HR (95%CI)

P-value

Age

 (≥60 vs. < 60 years)

1.794 (1.474–2.183)

< 0.001

1.429 (1.047–1.952)

0.025

Sex

 (Female vs. male)

0.879 (0.726–1.064)

   

KPS

 (< 80 vs. ≥80)

2.152 (1.554–2.979)

< 0.001

1.387 (0.968–1.989)

0.075

MGMT promoter status

 (Methylated vs. unmethylated)

0.742 (0.585–0.941)

0.013

0.896 (0.659–1.220)

0.487

Chemotherapy

 (Yes vs. no)

0.434 (0.337–0.557)

< 0.001

0.453 (0.277–0.739)

0.002

Radiotherapy

 (Yes vs. no)

0.571 (0.466–0.701)

< 0.001

0.653 (0.437–0.975)

0.037

Subtype

    

 ME vs. non-ME

1.269 (1.034–1.558)

0.016

1.323 (0.960–1.822)

0.087

miR-504/FZD7 ratio

 (Low vs. high)

1.511 (1.239–1.844)

< 0.001

1.542 (1.059–2.245)

0.024

  1. 95% CI 95% confidence interval, KPS Karnofsky performance status
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Journal of Experimental & Clinical Cancer Research

ISSN: 1756-9966

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