An essential role of RNF187 in Notch1 mediated metastasis of hepatocellular carcinoma

Table 2 Association of RNF187 expression with clinicopathological factors of the HCC patients in Cohort I and Cohort II

Clinicopathological variables		Cohort I				Cohort II
		n	RNF187 expression		^aP value	n	RNF187 expression		^aP value
		n	Low (n = 79)	High (n = 71)	^aP value	n	Low (n = 34)	High (n = 33)	^aP value
Sex	Male	122	61	61	0.172	54	26	28	0.386
Sex	Female	28	18	10	0.172	13	8	5	0.386
Age, years	≤ 50	63	34	29	0.786	38	22	16	0.180
Age, years	> 50	87	45	42	0.786	29	12	17	0.180
Serum AFP, ng/mL	≤ 20	63	35	28	0.546	23	6	17	0.004
Serum AFP, ng/mL	> 20	87	44	43	0.546	44	28	16	0.004
Tumor nodule number	Solitary	123	66	57	0.604	52	26	26	0.820
Tumor nodule number	Multiple	27	13	14	0.604	15	8	7	0.820
Maximal tumor size, cm	≤ 5	69	43	26	0.029	37	21	16	0.274
Maximal tumor size, cm	> 5	81	36	45	0.029	30	13	17	0.274
Microvascular invasion	Absent	68	40	28	0.169	39	19	20	0.695
Microvascular invasion	Present	82	39	43	0.169	28	15	13	0.695
Tumor differentiation	Well	19	12	7	0.327	22	7	15	0.030
Tumor differentiation	Moderately or poorly	131	67	64	0.327	45	27	18	0.030
TNM stage	I and II	97	59	38	0.007	47	21	26	0.128
TNM stage	III and IV	53	20	33	0.007	20	13	7	0.128

^a Pearson chi-square test was used for comparison between subgroups. Significant results (P < 0.05) are given in bold

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