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Table 2 Association of RNF187 expression with clinicopathological factors of the HCC patients in Cohort I and Cohort II

From: An essential role of RNF187 in Notch1 mediated metastasis of hepatocellular carcinoma

Clinicopathological variables Cohort I Cohort II
n RNF187 expression aP value n RNF187 expression aP value
Low (n = 79) High (n = 71) Low (n = 34) High (n = 33)
Sex Male 122 61 61 0.172 54 26 28 0.386
Female 28 18 10 13 8 5
Age, years ≤ 50 63 34 29 0.786 38 22 16 0.180
>  50 87 45 42 29 12 17
Serum AFP, ng/mL ≤ 20 63 35 28 0.546 23 6 17 0.004
>  20 87 44 43 44 28 16
Tumor nodule number Solitary 123 66 57 0.604 52 26 26 0.820
Multiple 27 13 14 15 8 7
Maximal tumor size, cm ≤ 5 69 43 26 0.029 37 21 16 0.274
>  5 81 36 45 30 13 17
Microvascular invasion Absent 68 40 28 0.169 39 19 20 0.695
Present 82 39 43 28 15 13
Tumor differentiation Well 19 12 7 0.327 22 7 15 0.030
Moderately or poorly 131 67 64 45 27 18
TNM stage I and II 97 59 38 0.007 47 21 26 0.128
III and IV 53 20 33 20 13 7
  1. a Pearson chi-square test was used for comparison between subgroups. Significant results (P < 0.05) are given in bold