Fig. 2
(A-B) Plasma pharmacokinetic profiles of fenretinide after single oral administration of different Bio-nFeR doses. a Comparison of the fenretinide plasma concentration decay curves after administration of the indicated Bio-nFeR oral doses. b Cmax and AUC of fenretinide as function of the administered dose of Bio-nFeR. c-d Pharmacokinetic profile in acute and chronic administration of Bio-nFeR compared to NCI-FeR. c Pharmacokinetic profile of oral Bio-nFeR in comparison with fenretinide NCI formulation after acute treatment (left) or 2 weeks of chronic treatment (right). d Pharmacokinetic profile of oral Bio-nFeR and its metabolites as single administration or chronic treatment and its metabolites in the same samples as in C