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Fig. 6 | Journal of Experimental & Clinical Cancer Research

Fig. 6

From: Long noncoding RNA 00976 promotes pancreatic cancer progression through OTUD7B by sponging miR-137 involving EGFR/MAPK pathway

Fig. 6

Linc00976 promotes OTUD7B-mediated EGFR deubiquitination and MAPK pathway activation. a Cytoscape showed the OTUD7B interaction proteins base on the Immunoprecipitation-MS (Mass Spectrometry). b and c Co-immunoprecipitation and immunofluorescent staining analysis the interaction between OTUD7B and EGFR. d The protein degradation assay analysis the stability of EGFR in OTUD7B overexpress NC group cells over the indicated time. e The ubiquitination assay showed that the ubiquitination level of EGFR in OTUD7B overexpressed and downregulated PC cells. f Western-blot indicated the expression and activity in EGFR downstream pathway MAPK in OTUD7B overexpressed and downregulated PC cells

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