Fig. 5From: Zebrafish modeling reveals that SPINT1 regulates the aggressiveness of skin cutaneous melanoma and its crosstalk with tumor immune microenvironmentSpint1a deficiency both in stromal and tumor cell enhances SKCM dissemination in zebrafish larval model. a Allotransplant experimental design. Combinations of Spint1a-deficient tumor and stromal cells from SKCMs were mixed with wild type tumor and stromal cells. All possible cell combinations were obtained maintaining the initial ratio. b Representative images (overlay of bright field and red channels) of the invasion in wild type recipient larvae at 5 dpi. Bar: 500 μm. c Number of tumor foci per larva (n = 5 SKCM tumors). **p < 0.01 according to a Chi-square TestBack to article page