Fig. 6

Spint1a-deficient SKCM shows enhanced aggressiveness in adult zebrafish allotransplantation assays. a Experimental workflow of adult allotransplantation experiments in pre-irradiated adult casper zebrafish. b Percentage of engraftment for both control and Spint1a-deficient tumors. Each dot represents a single SKCM tumor and the mean ± SEM is also shown (n = 5). c and d Representative images and average tumor size (pixels) from 1 to 4 weeks post-transplant of primary (c) and secondary (d) transplants. Each dot corresponds to a recipient-transplanted fish and the mean ± SEM is also shown. b-d *p < 0.05, **p < 0.01, ***p < 0.001 according to unpaired Student t test