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Fig. 3 | Journal of Experimental & Clinical Cancer Research

Fig. 3

From: ACLY facilitates colon cancer cell metastasis by CTNNB1

Fig. 3

Loss of ACLY significantly weakened the invasive ability in vivo. a The PET or PET-CT images of nude mice metastasis model by tail vein injection of 18F-FDG. The arrow pointed to the high metabolite of 18F-FDG concentration. b Comparison of the maximum standard 18F-FDG uptake value (SUV max) between tumor tissues and surrounding normal tissues in the control group. c The protein levels of ACLY and E-cadherin in liver and lung tissues of the control and KO group detected by western blot. Actin was the loading control. d-h Pictures of representative lung or liver tissues (D) and tissue sections of intrahepatic and pulmonary metastases (e) were shown, the area quantification of intrahepatic and pulmonary metastatic foci was analyzed by Student’s t-test (f). Pictures of representative HE staining, Ki67 staining and ACLY staining of metastatic lesion and precancerous tissue in lungs (g) and livers (h). Scale bar: 2000 μm (e); 200 μm (g and h)

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