Fig. 7
From: ACLY facilitates colon cancer cell metastasis by CTNNB1
Schematic representation of ACLY and CTNNB1 implicated in colon cancer metastasis. ACLY interacted with CTNNB1 and might block the ubiquitination of CTNNB1, and subsequently promoted CTNNB1 translocation through cellular cytoplasm to nucleus. The binding of CTNNB1 to LEF in the nucleus further activated transcription factors such as Snail and repression of E-cadherin, promoting the metastasis of tumor cells. ACLY: ATP citrate lyase, Ub: ubiquitination, LEF: lymphoid enhancer-binding protein