Fig. 3
Knockdown of circDENND4C suppresses migration and invasion in breast cancer cells under hypoxia. Cell migration, invasion (a-d) and the protein levels of MMP9 and MMP2 (e and f) were detected in MDA-MB-453 and SK-BR-3 cells transfected with siRNA against circDENND4C (si-circ) or siRNA negative control (si-NC) after treatment of hypoxia by trans-well assay and western blot. **P < 0.01, ***P < 0.001