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Fig. 6 | Journal of Experimental & Clinical Cancer Research

Fig. 6

From: Knockdown of circDENND4C inhibits glycolysis, migration and invasion by up-regulating miR-200b/c in breast cancer under hypoxia

Fig. 6

miR-200b deficiency reverses silence of circDENND4C-mediated progression inhibition in breast cancer cells under hypoxia. Glucose consumption (a and b), lactate production (c and d), HK2 protein level (e and f), cell migration (g and h), invasion (i and j) and protein levels of MMP9 and MMP2 (k and l) were measured in MDA-MB-453 and SK-BR-3 cells transfected with siRNA negative control (si-NC), siRNA against circDENND4C (si-circ), si-circ and miR-200b inhibitor (anti-miR-200b) or inhibitor negative control (anti-miR-NC) by special commercial kits, western blot and trans-well assay, respectively. *P < 0.05, **P < 0.01, ***P < 0.001

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