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Fig. 7 | Journal of Experimental & Clinical Cancer Research

Fig. 7

From: Methylation-mediated silencing of miR-133a-3p promotes breast cancer cell migration and stemness via miR-133a-3p/MAML1/DNMT3A positive feedback loop

Fig. 7

Effects of MAML1-targeted miR-133a-3p on the growth of MCF-7 cell xenografts in mice. a, b miR-133a-3p levels (a) and MAML1 protein levels (b) in MCF-7 cells transfected with either the control lentivirus, miR-133a-3p sponge lentivirus, MAML1 sponge lentivirus, or miR-133a-3p sponge lentivirus plus MAML1 sponge lentivirus. c Experimental design: the indicated stable MCF-7-expressing cell lines were subcutaneously implanted into nude mice via the armpit. d-f The tumor growth of mice subcutaneously implanted with the indicated MCF-7 cells. Tumor volume (d) and weight (e) were measured, and tumor size is pictured (f). g, h Representative H&E-stained sections (g) and immunohistochemical staining of Ki-67 and MAML1 of the tumors from subcutaneously implanted mice. Scale bar, 100 μm. *P < 0.05; **P < 0.01; ***P < 0.001

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