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Fig. 3 | Journal of Experimental & Clinical Cancer Research

Fig. 3

From: Elevated TRIP13 drives the AKT/mTOR pathway to induce the progression of hepatocellular carcinoma via interacting with ACTN4

Fig. 3

TRIP 13 silencing inhibited tumor growth and lung metastasis in vivo. a MHCC97H cells with different TRIP13 expression were subcutaneously transplanted the xenograft into BALB/c nude mice (n = 6/group) and tumor sizes were measured after 4 weeks. b Tumor weights were measured. c Tumors were formalin-fixed, paraffin-embedded, sliced and stained with TRIP13 and PCNA. Representative images of each group are presented. d-e MHCC97H cells with different TRIP13 expression were injected into BALB/c nude mice (n = 6/group) through the tail vein to establish lung metastasis models. The number of lung metastatic nodules in each group was counted under the microscope. Representative H&E staining images of lungs were shown. **s < 0.01

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