Fig. 5

TRIP13 altered activation of PI3K/AKT/mTOR pathway to induce cell EMT. a Gene set enrichment analysis of TCGA LIHC dataset showed enrichment of PI3K/AKT/mTOR pathway and Wnt/β-catenin pathway gene panels in the TRIP13 high expression group. b Reprehensive genes of PI3K/AKT/mTOR pathway and Wnt/β-catenin pathway were detected in TRIP13 knockdown or overexpression cells. c-d Cells were treated with XAV939 or LY294002 and cell migration and invasion were measured. e Cells were treated with XAV939 or LY294002 and the levels of EMT markers were analyzed. *P < 0.05, **P < 0.01, ***P < 0.001