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Table 1 Univariate and multivariate analysis of TRIP13 in OS of 96 HCC patients

From: Elevated TRIP13 drives the AKT/mTOR pathway to induce the progression of hepatocellular carcinoma via interacting with ACTN4

Variables   Univariate analysis Multivariate analysis
HR 95%CI P-value HR 95%CI P-value
Age (year) <50 vs. ≥50 0.854 0.519-1.408 0.537 NA   
Gender male vs. female 2.159 1.026-4.540 0.042 NA   
Tumor size (cm) ≤5 vs. >5 1.806 1.087-3.001 0.004a 1.589 0.951-2.655 0.077
Tumor number mutiple vs. single 0.693 0.381-1.258 0.227 NA   
Tumor differentiation I-II vs. III-IV 1.191 0.674-2.104 0.548 NA   
Microvascular invasion yes vs. no 2.589 1.562-4.290 0.000224a 2.345 1.410-3.900 0.001a
HBsAg positive vs. negative 0.699 0.355-1.377 0.301 NA   
History of cirrhosis yes vs. no 1.716 0.843-3.494 0.137 NA   
TNM stage I-II vs. III-IV 1.555 0.927-2.608 0.095 NA   
TRIP13 low vs. high 2.125 1.265-3.571 0.004a 1.816 1.074-3.070 0.026a
  1. Note: Univatiate and multivariate analysis, Cox proportional hazards regression model. OS Overall survival time, HR Hazard ratio, CI Confidence interval, NA Not applicable
  2. aStatistically significant