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Table 1 Univariate and multivariate analysis of TRIP13 in OS of 96 HCC patients

From: Elevated TRIP13 drives the AKT/mTOR pathway to induce the progression of hepatocellular carcinoma via interacting with ACTN4

Variables

 

Univariate analysis

Multivariate analysis

HR

95%CI

P-value

HR

95%CI

P-value

Age (year)

<50 vs. ≥50

0.854

0.519-1.408

0.537

NA

  

Gender

male vs. female

2.159

1.026-4.540

0.042

NA

  

Tumor size (cm)

≤5 vs. >5

1.806

1.087-3.001

0.004a

1.589

0.951-2.655

0.077

Tumor number

mutiple vs. single

0.693

0.381-1.258

0.227

NA

  

Tumor differentiation

I-II vs. III-IV

1.191

0.674-2.104

0.548

NA

  

Microvascular invasion

yes vs. no

2.589

1.562-4.290

0.000224a

2.345

1.410-3.900

0.001a

HBsAg

positive vs. negative

0.699

0.355-1.377

0.301

NA

  

History of cirrhosis

yes vs. no

1.716

0.843-3.494

0.137

NA

  

TNM stage

I-II vs. III-IV

1.555

0.927-2.608

0.095

NA

  

TRIP13

low vs. high

2.125

1.265-3.571

0.004a

1.816

1.074-3.070

0.026a

  1. Note: Univatiate and multivariate analysis, Cox proportional hazards regression model. OS Overall survival time, HR Hazard ratio, CI Confidence interval, NA Not applicable
  2. aStatistically significant