Fig. 8From: Inhibiting PAD2 enhances the anti-tumor effect of docetaxel in tamoxifen-resistant breast cancer cellsSchematic of the synergistic effects of cl-amidine and docetaxel on p53/Akt/mTOR signaling in regulation of genes associated with cell apoptosis, cell cycle arrest and autophagy. Inhibiting PAD2 reverses p53 degradation, leading to the enhanced p53 nuclear accumulation with docetaxel co-treatment, thus accelerating cell apoptosis and cell cycle arrest. The combination treatment also promotes the autophagy processes by synergistically inhibiting Akt/mTOR signing, leading to the enhanced proliferation inhibitionBack to article page