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Fig. 6 | Journal of Experimental & Clinical Cancer Research

Fig. 6

From: Programmed cell death ligand-1-mediated enhancement of hexokinase 2 expression is inversely related to T-cell effector gene expression in non-small-cell lung cancer

Fig. 6

HK2 expression is inversely correlated with the expression of T-cell effector molecules in human lung cancers, particularly in those with high PD-L1 expression. a The expression levels of T-cell effector molecules, including CD4, CD8A, GZMA, GZMB, IFNG, CXCL9, CXCL10 and PRF1, were assessed according to CD274 (PD-L1) and HK2 expression status in NSCLCs from TCGA dataset (N = 1015). Cases were dichotomized into PD-L1low and PD-L1high groups based on median values and then trichotomized into HK2low (<25th percentile), HK2intermediate (25-75th percentile), and HK2high (>75th percentile) groups. Statistical differences were analyzed using Kruskal-Wallis tests. b and c The expression levels of T-cell effector molecules were compared according to HK2 expression status in NSCLCs with low CD274 (PD-L1) mRNA levels (b) and with high CD274 (PD-L1) mRNA levels (c) in NSCLCs from TCGA dataset. Statistical significance was calculated using Pearson’s correlation analyses. *p < 0.05; **p < 0.001. Abbreviations: L, low; I, intermediate; H, high

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