Fig. 1
From: Targeting T cell metabolism in the tumor microenvironment: an anti-cancer therapeutic strategy
Metabolic reprogramming of T cell subsets in tumor microenvironment. Tumor mainly use glycolysis to produce energy. Glucose competition, amino acid competition, and lactic acid secretion in the tumor microenvironment influence the subsets of T cells. Tregs mainly produce energy by oxidative phosphorylation (OXPHOS) and fatty acid oxidation (FAO). Similar to Treg, memory T cells maintain basic functions by increasing FAO. However, activated Teffs primarily depend on glycolysis and fatty acid synthesis